|
KMID : 1007020030010020140
|
|
Korean Soceity of Osteroporosis
2003 Volume.1 No. 2 p.140 ~ p.148
|
|
|
Association Study of the Relationship Between Polymorphism of the Interleukin-6 Gene and Bone Mineral Density in Korean Menopausal Women
|
|
Lee So-Hyun
Lee Kyung-Ah
Hur Sung-Eun
Moon Hye-Sung
Chung Hye-Won
|
|
|
Abstract
|
|
|
Objectives: To investigate a possible relationship between single nucleotide polymorphism of human IL-6 promoter -572 locus and BMDs of distal radius and distal calcaneous of Korean menopausal women.
Methods: We examined BMDs of 234 postmenopausal Korean women(by DEXA) and extracted DNAs from peripheral blood samples. Polymerase chain reaction was used to detect IL-6 gene polymorphism.
Results: The mean age, height, weight and BMI of patients were respectively 50.8±7.9years, 153.3±5.0cm, 57.8±7.3kg and 23.9±2.8kg/m2. The genotype distribution was as follows; GG genotype, 119(50.9%) women; GC genotype, 103(44.0%) women; CC genotype, 12(5.1%) women. BMDs of distal radius in genotype GG, GC, CC were 1.03±0.17g/cm2, 1.04±0.18g/cm2, 1.00±0.17g/cm2, respectively. They were not significantly different(p>0.05). BMDs of distal calcaneus were -0.84±1.40g/cm2, -0.70±1.43g/cm2, -0.96±1.66g/cm2, respectively. There was no statistical significance in BMD in each genotypes(p>0.05).
Conclusion: We concluded that IL-6 -572 SNP didn’t have an association with BMD of postmenopausal Korean women. IL-6 promoter -572 SNP would not be a single genetic factor of postmenopausal osteoporosis.
|
|
|
KEYWORD
|
|
|
Interleukin-6, Bone Mineral Density, SNP, Menopause
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|